Kousei Arima was a genius pianist until his mother's sudden death took away his ability to play. Each day was dull for Kousei. But, then he meets a violinist named Kaori Miyazono who has an eccentric playing style. Can the heartfelt sounds of the girl's violin lead the boy to play the piano again?

The dark fantasy follows a high school sophomore named Akihito Kanbara. Although the boy appears human, he is half Youmu and invulnerable to wounds because he can heal quickly. One day, Akihito meets freshman Mirai Kuriyama when it seems she is about to jump from the school rooftop. Mirai is isolated because of her ability to manipulate blood, which is considered heresy among members of the spirit world. Disturbing events begin to unfold after Akihito saves Mirai.

Kojou Akatsuki's days as an ordinary high school student in the Demon District of Itogami Island come to an abrupt end after a fateful encounter leaves him with the remarkable abilities of a vampire. It isn't long before he is thrust into the center of attention when it is discovered that he is the fourth primogenitor, an immensely powerful vampire whom most consider to be merely a legend. Fearing Kojou's destructive potential, the Lion King Organization sends in an apprentice sword-shaman, Yukina Himeragi, to monitor, and should he become a threat, kill the boy deemed the world's most powerful vampire. Forced together by circumstance, the two form an unlikely alliance as Kojou comes to terms with his abilities and they both struggle to protect the city from various emerging chaotic forces.

Hakuoro has lost his memory after succumbing to serious injuries. But thanks to an elderly woman and her granddaughter Eruruu, he is nursed back to health. His face is covered by a strange irremovable mask and he occasionally sees beastly visions. Eruruu now cares for him as he becomes accustomed to the village and its inhabitants, who all bear strange ears (the women also have tails). Though these people venerate the forces of nature, desecration of an altar forces them to take drastic measures to preserve their lives from the wrath of Mutikapa-sama, guardian of the forest.

Mikiya Kokutou gives Shiki Ryougi a cat to watch, as he will be away for a little while. Though Shiki protests, he leaves the cat anyway, and Shiki is stuck trying to understand her new feline companion. But as luck would have it, the cat seems to have taken a liking to Mikiya and misses him. Later in another part of the city, Ririsu Miyazuki visits the place where her dear friend committed suicide. She intends to end her life as well, but she meets Fujino Asagami, a blind classmate with a traumatic past. Though the two girls don't have much in common, Asagami reminds Miyazuki of her lost friend and helps her understand her pain. Two months later, Mikiya elects to celebrate New Year's with Shiki instead of his family, which makes his sister Azaka very upset, leading to her spending the holiday with her school friends. As the snow begins to fall, Mikiya reflects on what he wishes for most of all: that Shiki's life be filled with happiness.