When Betty Anne Waters' older brother Kenny is arrested for murder and sentenced to life in 1983, Betty Anne, a Massachusetts wife and mother of two, dedicates her life to overturning the murder conviction. Convinced that her brother is innocent, Betty Anne puts herself through high school, college and, finally, law school in an 18 year quest to free Kenny. With the help of best friend Abra Rice, Betty Anne pores through suspicious evidence mounted by small town cop Nancy Taylor, meticulously retracing the steps that led to Kenny's arrest. Belief in her brother - and her quest for the truth - pushes Betty Anne and her team to uncover the facts and utilize DNA evidence with the hope of exonerating Kenny.

90210 revolves around several students at the fictional West Beverly Hills High School, including new Beverly Hills residents Annie Wilson and Dixon Wilson. Their father, Harry Wilson, has returned from Kansas to his Beverly Hills childhood home with his family to care for his mother, former television and theater actress Tabitha Wilson, who has a drinking problem and clashes with his wife Debbie Wilson. Annie and Dixon struggle to adjust to their new lives while making friends and yet adhering to their parents' wishes.

Notorious serial killer Joe Carroll, after being found guilty of murdering 14 female students on the Virginia college campus where he taught literature, escapes from death row. The FBI calls former agent Ryan Hardy to consult on the case, as he was the one responsible for Carroll’s capture in 2003. Ryan, working closely with an FBI team, including Mike Weston and FBI Specialist Debra Parker, piece together the ever-growing web of murders orchestrated by the devious Carroll.