After Megamind, a highly intelligent alien supervillain, defeats his long-time nemesis Metro Man, Megamind creates a new hero to fight, but must act to save the city when his "creation" becomes an even worse villain than he was.

Ordered to teach a martial arts class of rambunctious bunny kittens, Po tells stories of each of the Furious Five's pasts.

Iris and Isaac's first romantic weekend getaway as a couple goes awry. Convinced she's met her perfect guy and that he's just confused, Iris goes to increasingly ridiculous and irrational lengths to prove to Isaac that they are meant to be together.

A documentary team gets a grant to do a film on a rare fatal disease that is attacking homeless people. However, they quickly find the film too depressing. Ducking into a nightclub, they discover a young Manhattan comedienne and decide instead to follow her as she makes the circuit of auditions in L.A. as she tries to get a TV pilot. Unfortunately, she has failed to tell her boyfriend of this move. He decides he will trail her out west. There, the boyfriend runs into an old friend who has already made a break on a TV pilot. Seizing the opportunity, the actress turns her attentions to the established actor. However, the actress goes nowhere in auditions, but her ex-boyfriend is suddenly noticed and becomes the next hot prospect.

From the immediate aftermath of 9/11 to today stand-up comedians, talk-show hosts, sketch performers, television animators and other entertainers have used often-controversial jokes to unite and heal in the face of tragedy.